Renal Genome Network (ReGeNet)
ReGeNet is an investigator-led pan European network of researchers in Nephrology and Genetics with the overall aim of generating and translating novel insights from genomic and genetic studies to the clinical benefit of the renal patient.
To this purpose, the scientific aims are to elucidate the genetic determinants of renal damage and its complications, both with respect to natural course and the response to therapeutic intervention:
- genes influencing the development of co-morbid disease e.g. accelerated cardiovascular disease in uremia
- the interactions between gene and therapy for chronic kidney disease e.g. dialysis modality, transplantation and drug treatment
- genes predicting outcome of therapeutic modalities.
ReGeNet pursues its aims by promoting and facilitating clinical studies of genetic epidemiology in renal disease by, first:
- establishing large numbers of patients at different stages of renal damage with clearly defined phenotype for collaborative study by the network
- establishing new cohorts and coordinating the availability of existing renal cohorts for prospective study by the network
- validating genotyping methodology and seeking integration of data capture and storage
- providing expertise in molecular genetics and genomics, genetic statistics, epidemiology and bioinformatics
- enabling the study of rare renal conditions and morbidities
- providing education, training opportunities and exchange for young investigators
- promoting quality, best practice and high standards of research governance
and second, by promoting dissemination of data from genetic renal research to the clinical community, including parties involved in guideline development.
Publication: Brenchley PE, Lindholm B, Dekker FW, Navis G on behalf of the Renal Genome Network, Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet). Nephrology Dialysis Transplantation 2006; 21:2681-2683.
For research activities and publications in the projects within ReGeNet, please visit the project websites.